Latest technologies from Thomas Jefferson University

Dual function tamper seal for a consumer test kit

adam.greenspan@jefferson.edu — Wed, 05 Jun 2019 10:43:32 GMT

In context of the opioid epidemic and the recent rise of accidental overdoses, Jefferson researchers have developed two substance testing kits, one for fentanyl and one for substances such as MDMA and heroin. There currently are no substance testing kits on the market that are specifically designed for the consumer. Corrosive reagents, small accessories and difficult to follow instructions make them dangerous and difficult to conduct outside of a laboratory setting. Research suggests that allowing a user to self test for laced substances may decrease instances of accidental overdose.A novel fe...

Developing Imaging Bio Markers for Pediatric Spinal Cord Imaging

adam.greenspan@jefferson.edu — Thu, 30 May 2019 08:42:58 GMT

This technology is software that provides a novel, quantitative assessment of the functional characteristics of the human spinal cord (adult or pediatric) by generating an axonal damage map that will help identify different injury/diseased states along the entire spinal cord. The market is the population of clinicians who are interested in advanced imaging of the spinal cord but lack the in-house resources to perform the required analysis. Currently, functional imaging of the spinal cord requires expertise in image acquisition, image processing, and analysis. This software will enable clinicia...

Dual function tamper seal for a consumer test kit

adam.greenspan@jefferson.edu — Thu, 30 May 2019 07:16:22 GMT

Positioning cushion for needle placement into a lumbar interlaminar space

adam.greenspan@jefferson.edu — Wed, 14 Nov 2018 11:07:25 GMT

Portable pelvic examination positioning device

adam.greenspan@jefferson.edu — Wed, 14 Nov 2018 10:44:16 GMT

Surgical face mask capable of identifying patients at risk of spreading viral infection

adam.greenspan@jefferson.edu — Thu, 04 Oct 2018 12:29:42 GMT

Temperature-sensitive Surgical Face Mask for Identifying at-risk Patients and Reducing Viral Infection Summary & Detailed DescriptionHospitals need a quick and inexpensive method for triaging virus-infected patients while limiting exposure to others. A novel hospital face mask concept incorporates one or more thermochromatic materials to provide a clear color indicator on the basis of temperature. These thermochromatic materials may be provided in a liquid or aerosol form, that are color-changed in the presence of an active fever, i.e. a temperature over 98.6 degrees Fahrenheit. The i...

Angled Cranial Drill (Craniotome)

adam.greenspan@jefferson.edu — Thu, 04 Oct 2018 11:23:37 GMT

Angled Craniotomy Drill Introduction & Summary Instruments designed to perform the craniotomy are called craniotomes. Craniotomes typically include a cutting bit with a footplate disposed axially perpendicular to the cutting bit. The footplate protects the underlying tissue from contacting the cutting bit when a cut is made perpendicular to the surface of the skull. However, a problem arises when a cut is made at an angle relative to the surface of the skull because the underlying tissue can contact the cutting bit, causing damage to the tissue. Additionally, a perpendicular cut also ...

Electrode lead and method for epileptogenic brain localization and functional mapping in stereotactic thermal therapy

adam.greenspan@jefferson.edu — Thu, 04 Oct 2018 11:20:50 GMT

Electrode Lead & Method for Epileptognic Brain Localization & Functional Mapping in Stereotatic Thermal Therapy Background and Summary Nearly half of thermal ablation procedures have a less than an ideal post-operative seizure outcome. A possible explanation is that the epileptogenic focus is not completely delineated prior or during the performance of this surgical procedure. The post-operative seizure outcome from LITT for medically refractory focal epilepsy would be improved if epileptogenic foci could be better delineated. Many different methods have been used in attempt to de...

Antibiotic Drug Release Clip (Co-owned with Drexel IIA 60-40 split expenses and revenue TJU Drexel)

adam.greenspan@jefferson.edu — Thu, 04 Oct 2018 11:10:45 GMT

Antibiotic Drug Release Clip Background and SummaryThis device is an antibiotic drug release clip. The advantage of this device over the current practice is that antibiotic is released post removal of suture drains so no drug will leak out through these conduits. The application of ultrasound is completely non-invasive (unlike injection), so it does not contribute to patient suffering. Not only will the application of ultrasound rupture the PLA membrane, releasing the drug into the wound site, sonication will also mobilize adherent bacteria making them more susceptible to antibiotics. Thi...

Gas Filled Surfactant Microbubbles (Joint w/ Drexel. Drexel is the lead)

adam.greenspan@jefferson.edu — Thu, 04 Oct 2018 11:06:37 GMT

Surfactant Microbubbles and Process for Preparing and Methods of Using the Same Background & Summary It has been well documented that chronically hypoxic tumor microenvironments result in both chemotherapy and radiation therapy resistance and pose a major hurdle for effective radiation therapy. In addition, therapy resistance is more pronounced at lower PO2 levels (<20 mmHg), but can be overcome almost instantaneously via localized oxygen delivery. Thus, a rapid, efficient method for locally delivering O2 immediately prior to radiotherapy would be immensely beneficial in overc...

A new way of stimulating the nerves fibers in the lumbar area to relieve severe intractable low back pain

adam.greenspan@jefferson.edu — Thu, 04 Oct 2018 11:01:17 GMT

Subcutaneous Electrodes for Treating Severe Pain in the Lumbar Region Summary & Detailed DescriptionThis device stimulates the nerve fibers in the lumbar area to relieve sever intractable lower back pain. The procedure entails implanting percutaneous electrodes in the subcutaneous tissues directly in the area of the pain in the lumbar area. This methodology involves minimal risks, since the electrodes are just placed under the skin. The novel concept is one of placing the electrodes directly over the painful area, but to have them implanted in the subcutaneous tissues. This causes an ...

Pure Protein Nanoparticles for Drug Delivery (Inventor Share Uneven Distribution)

adam.greenspan@jefferson.edu — Thu, 04 Oct 2018 10:49:10 GMT

Novel Hybrid Nanoparticles for Therapeutics Delivery Background & Summary Medicines of the 21st century are becoming increasingly targeted to the specific molecular pathway in the particular cells of the tissue or organ that is diseased. Broad acting drugs are giving way to precision medicines that show disease specificity, strong efficacy and reduced side effects or toxicities. While siRNA and other nucleotides have proven to be therapeutically effective, there is currently no non-viral delivery system on the market yet for administering these to successfully achieve gene knockdown. ...

Patient Isolation Indicator Tag

adam.greenspan@jefferson.edu — Thu, 04 Oct 2018 10:28:01 GMT

Patient Isolation Indicator Tag Background & Summary With the rise in antibiotic resistant bacteria and highly transmissible infections, disinfecting contaminated surfaces is of high importance in reducing healthcare associated infections. Furthermore, patients visit multiple areas in hospitals for diagnostic testing, procedures and surgeries, but patients will not always be transported with a paper chart. There is often a gap in communication when transporting staff drops a patient off at the receiving department. They may forget to mention that the patient is on isolation, and then ...

A POCKETSIZED SMART PHONE ACCESSORY MEDICAL AUTO-INJECTOR

adam.greenspan@jefferson.edu — Thu, 04 Oct 2018 10:24:40 GMT

Auto-injector Incorporated into a Portable Electronic Device Case Background and Summary Every year, individuals die of allergic reactions because no EpiPen® or comparable product is immediately available. Folks simply do not always carry these devices in their purses, backpacks, pockets, etc., and so they may not be available when absolutely needed. Today nearly everyone carries a cell phone. An epinephrine delivery device that attached as an aftermarket case to a cell phone would save many lives by providing immediate access to epinephrine in the case of an allergic reaction. The J...

Healthy Hands Network: A method and system to occupy a subject while ensuring accordance with specific protocols for hand hygiene

adam.greenspan@jefferson.edu — Tue, 17 Apr 2018 08:32:44 GMT

Over 700,000 Americans each year are affected by infections acquired from health care providers or settings, and over 75,000 die from these incidents. The CDC estimates that there is at least one in 25 patients with a healthcare-acquired infection every day. Research shows proper hand washing procedure could lower these numbers. Nonetheless, many healthcare workers do not wash their hands for the minimum recommended 20 seconds and often times spend less than ten seconds on this task. Jefferson researchers created a novel method and device designed to provide a positive experience for the hand ...

Percutaneous tendon/fascia repair via needle using imaging guidance (Returned to Inventor)

adam.greenspan@jefferson.edu — Thu, 04 Jan 2018 09:40:39 GMT

Percutaneous tissue-to-bone fixation device Brief DescriptionGluteus tendon tears (hip abductor injury) and sports hernia (groin injury), are common in the older population and athletes, respectively; these injuries involve the tendon being stripped off of the bone. State of the art minimally invasive solutions for such tendon tears include a substrate injection but so far this procedure has demonstrated little proven clinical benefit. Another current treatment regimen is open surgery that yields a better recovery but is costly, time intensive, and has a higher risk for complications. Add...